abstract：:In this study, we demonstrate that EGF inhibits the TGF-β1-induced apoptosis of Huh7 cells. TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway. TGF-β1 also inhibits the activation of S6 kinase 1 which phosphorylates the serine 67 res...

journal_title：Cellular signalling

authors： Matsuhashi S,Hamajima H,Xia J,Zhang H,Mizuta T,Anzai K,Ozaki I

更新日期：2014-03-01 00:00:00

abstract：:The Rho family of GTPases consists of several small proteins that have been described as molecular switches, playing important roles in a wide variety of fundamental cellular processes and in human diseases such as cancer. These proteins, active in the GTP conformation and inactive in the GDP form, are in turn regulat...

journal_title：Cellular signalling

authors： Boissier P,Huynh-Do U

更新日期：2014-03-01 00:00:00

abstract：:Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. However the relative role of each pathway and how they interact are not understood. Here we delineate how Akt and Rac1 pathways signal to increa...

journal_title：Cellular signalling

authors： Sylow L,Kleinert M,Pehmøller C,Prats C,Chiu TT,Klip A,Richter EA,Jensen TE

更新日期：2014-02-01 00:00:00

abstract：:TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed in pancreatic, thyroid, colon, and other cancer tissues. Previously, we demonstrated that TMPRSS4 mediates tumor cell invasion, migration, and metastasis. However, the mechanisms by which TMPRSS4 contributes to invasion are not fully und...

journal_title：Cellular signalling

authors： Min HJ,Lee Y,Zhao XF,Park YK,Lee MK,Lee JW,Kim S

更新日期：2014-02-01 00:00:00

abstract：:We previously showed that activated peroxisome proliferator-activated receptor (PPAR)β/δ can protect pancreatic β cells against lipotoxic apoptosis. However, the molecular mechanism remained unclear. Glucagon-like peptide-1 receptor (GLP-1R) has been reported to exhibit a protective effect against lipotoxic apoptosis ...

journal_title：Cellular signalling

authors： Yang Y,Tong Y,Gong M,Lu Y,Wang C,Zhou M,Yang Q,Mao T,Tong N

更新日期：2014-02-01 00:00:00

abstract：:Dysfunctional regulation of signaling pathways downstream of the insulin receptor plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. In this study we report both in vitro and in vivo experimental evidence for a role of Cullin-RING E3 ubiquitin ligase 7 (CRL7) in the regulation of insul...

journal_title：Cellular signalling

authors： Scheufele F,Wolf B,Kruse M,Hartmann T,Lempart J,Mühlich S,Pfeiffer AFH,Field LJ,Charron MJ,Pan ZQ,Engelhardt S,Sarikas A

更新日期：2014-02-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) plays a critical role in the pathophysiology of ovarian cancers. Previous studies have shown that LPA stimulates the proliferation of ovarian cancer cells via Gα12. The present study utilizing Protein/DNA array analyses of LPA-stimulated HeyA8 cells in which the expression of Gα12 was silen...

journal_title：Cellular signalling

authors： Ha JH,Ward JD,Varadarajalu L,Kim SG,Dhanasekaran DN

更新日期：2014-01-01 00:00:00

abstract：:Capsaicin (CAP), the pungent ingredient of chili peppers, inhibits growth of various solid cancers via TRPV1 as well as TRPV1-independent mechanisms. Recently, we showed that TRPV1 regulates intracellular calcium level and chromogranin A secretion in pancreatic neuroendocrine tumor (NET) cells. In the present study, w...

journal_title：Cellular signalling

authors： Skrzypski M,Sassek M,Abdelmessih S,Mergler S,Grötzinger C,Metzke D,Wojciechowicz T,Nowak KW,Strowski MZ

更新日期：2014-01-01 00:00:00

abstract：:Transforming growth factor β (TGF-β), a cytokine, and its receptors play a vital role during normal embryogenesis, cell proliferation, differentiation, apoptosis and migration. Ran-binding protein in the microtubule-organizing center (RanBPM) serves as a scaffold protein that has been shown to interact with many other...

journal_title：Cellular signalling

authors： Zhang J,Ma W,Tian S,Fan Z,Ma X,Yang X,Zhao Q,Tan K,Chen H,Chen D,Huang BR

更新日期：2014-01-01 00:00:00

abstract：:Interleukin 1 (IL-1) triggers the internalization of its cognate receptor from the plasma membrane. We recently demonstrated that this internalization is of critical importance for the IL-1-induced gene expression. In this study we report that the IL-1-induced activation of the small GTPase Rac1 requires receptor endo...

journal_title：Cellular signalling

authors： Windheim M,Hansen B

更新日期：2014-01-01 00:00:00

abstract：:Suppressor of fused (SUFU) is an essential negative regulator of the mammalian Hedgehog (HH) signaling pathway and its loss is associated with cancer development. On a cellular level, endogenous SUFU can mainly be detected in the cytoplasm and the nucleus. However, immunostaining of pancreatic cancer specimen revealed...

journal_title：Cellular signalling

authors： Tariki M,Wieczorek SA,Schneider P,Bänfer S,Veitinger S,Jacob R,Fendrich V,Lauth M

更新日期：2013-12-01 00:00:00

abstract：:Homer1 protein is an important scaffold protein at postsynaptic density and has been demonstrated to play a central role in calcium signaling in the central nervous system. The aim of this study was to investigate the effects of Homer1 knockdown on MPP(+) induced neuronal injury in cultured dopamine (DA) neurons. We f...

journal_title：Cellular signalling

authors： Chen T,Yang YF,Luo P,Liu W,Dai SH,Zheng XR,Fei Z,Jiang XF

更新日期：2013-12-01 00:00:00

abstract：:ASB proteins are the specificity subunits of cullin5-RING E3 ubiquitin ligases (CRL5) that play roles in ubiquitin-mediated protein degradation. However, how their activity is regulated remains poorly understood. Here, we unravel a novel mechanism of regulation of a CRL5 through phosphorylation of its specificity subu...

journal_title：Cellular signalling

authors： Zakaria R,Lamsoul I,Uttenweiler-Joseph S,Erard M,Monsarrat B,Burlet-Schiltz O,Moog-Lutz C,Lutz PG

更新日期：2013-12-01 00:00:00

abstract：:The β-catenin signaling axis is critical for normal embryonic development and tissue homeostasis in adults. We have previously shown that extracellular enzyme transglutaminase 2 (TG2) activates β-catenin signaling in vascular smooth muscle cells (VSMCs). In this study, we provide several lines of evidence that TG2 fun...

journal_title：Cellular signalling

authors： Deasey S,Nurminsky D,Shanmugasundaram S,Lima F,Nurminskaya M

更新日期：2013-12-01 00:00:00

abstract：:Understanding receptor activation is important for disease intervention. Activation of the receptor tyrosine kinase c-KIT is involved in numerous diseases including melanoma, mastocytosis, multiple myeloma and gastrointestinal stromal tumors. To better understand the regulation of activation, we studied the two c-KIT ...

journal_title：Cellular signalling

authors： Phung B,Steingrímsson E,Rönnstrand L

更新日期：2013-11-01 00:00:00

abstract：:mTORC2, the mammalian target of rapamycin complex 2 is activated by upstream growth factors, and performs two major functions, phosphorylation of AKT at the serine of 473 and cell cycle-dependent organization of actin cytoskeleton. However, the mechanisms through which mTORC2 is triggered by these signals remain uncle...

journal_title：Cellular signalling

authors： Xu Y,Lai E,Liu J,Lin J,Yang C,Jia C,Li Y,Bai X,Li M

更新日期：2013-11-01 00:00:00

abstract：:The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly invo...

journal_title：Cellular signalling

authors： Hanna S,El-Sibai M

更新日期：2013-10-01 00:00:00

abstract：:The interactions between kidney and thyroid functions have been known for many years, but how the thyroid affects the kidney function is largely unknown. Here we analyzed the role of T3 on the tubular epithelial-to-mesenchymal transition (EMT), which is recognized to play pivotal roles in the process of renal fibrosis...

journal_title：Cellular signalling

authors： Lu X,Chen Z,Liang H,Li Z,Zou X,Luo H,Guo W,Xu L

更新日期：2013-10-01 00:00:00

abstract：:Immune responses to pathogens are regulated by immune receptors containing either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibitory motif (ITIM). The important diarrheal pathogen enteropathogenic Escherichia coli (EPEC) require delivery and insertion of the bacteri...

journal_title：Cellular signalling

authors： Yan D,Quan H,Wang L,Liu F,Liu H,Chen J,Cao X,Ge B

更新日期：2013-09-01 00:00:00

abstract：:Calcineurin inhibitors such as cyclosporin A (CsA) and FK506 have been used in solid organ and hematopoietic stem cell transplantations to suppress immune function. However, these immunosuppresants are associated with severe endothelial dysfunction. We investigated whether CsA and FK506 induce endothelial dysfunction ...

journal_title：Cellular signalling

authors： Eguchi R,Kubo S,Ohta T,Kunimasa K,Okada M,Tamaki H,Kaji K,Wakabayashi I,Fujimori Y,Ogawa H

更新日期：2013-09-01 00:00:00

abstract：:Antiviral responses can be triggered by the cytoplasmic RNA helicase RIG-I that binds to viral RNA. RIG-I-mediated signaling stimulates the transcription factors IRF3 and NF-κB and their activation mechanisms have been intensively studied. Here we examined Sendai virus (SV)-mediated activation of the transcription fac...

journal_title：Cellular signalling

authors： Johnsen IB,Bergstroem B,Stiberg KA,Thommesen L,Anthonsen MW

更新日期：2013-09-01 00:00:00

abstract：:Tyrosine phosphorylation (Tyr-P) of focal adhesion kinase (FAK) regulates FAK activation. Phosphorylated FAK Tyr 397 binds Src family kinases (Src), which in turn directly phosphorylate FAK Tyr 576/577 to produce maximal FAK enzymatic activity. CB₁ cannabinoid receptors (CB₁) are abundantly expressed in the nervous sy...

journal_title：Cellular signalling

authors： Dalton GD,Peterson LJ,Howlett AC

更新日期：2013-08-01 00:00:00

abstract：:Dissemination of cancer cells to distant organ sites is the leading cause of death due to treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the importance of the development of inappropriate cell survival signaling for various steps in the metastatic process and have noted the particula...

journal_title：Cellular signalling

authors： Agarwal E,Brattain MG,Chowdhury S

更新日期：2013-08-01 00:00:00

abstract：:The small GTPase Rac1 plays a pivotal role in insulin-stimulated glucose uptake in skeletal muscle, which is mediated by GLUT4 translocation to the plasma membrane. However, regulatory mechanisms for Rac1 and its role in the signaling pathway composed of phosphoinositide 3-kinase and the serine/threonine kinase Akt re...

journal_title：Cellular signalling

authors： Nozaki S,Takeda T,Kitaura T,Takenaka N,Kataoka T,Satoh T

更新日期：2013-06-01 00:00:00

abstract：:Ephedrine (Eph) is one of alkaloids that has been isolated from the ancient herb ephedra (ma huang) and is used as the treatment of asthma, hypotension and fatigue. However, its molecular mechanism remains unknown. Thioredoxin-1 (Trx-1) is a redox regulating protein, which has various biological activities, including ...

journal_title：Cellular signalling

authors： Jia JJ,Zeng XS,Li Y,Ma S,Bai J

更新日期：2013-05-01 00:00:00

abstract：:In humans injured myocardium cannot avert the onset and progression of ventricular dysfunction because of limited regenerative ability of myocytes. Although limited renaissance of cardiomyocytes has been reported in human infarcted hearts, it is generally accredited that non-functional fibrous tissue replaces the dead...

journal_title：Cellular signalling

authors： Verma V,Purnamawati K,Manasi,Shim W

更新日期：2013-05-01 00:00:00

abstract：:Timeless was originally identified in Drosophila as an essential component of circadian cycle regulation, where its function is tightly controlled at the protein level by tyrosine phosphorylation and subsequent degradation. In mammals, Timeless has also been implicated in circadian rhythms as well as cell cycle contro...

journal_title：Cellular signalling

authors： O'Reilly LP,Zhang X,Smithgall TE

更新日期：2013-04-01 00:00:00

abstract：:Placental syncytiotrophoblasts formed by the fusion of cytotrophoblasts constitute the interface between maternal and fetal circulations. The syncytium, composed of a continuous layer of syncytiotrophoblasts, assumes the fetal-maternal nutrient exchange, placental barrier, and endocrine functions important for the mai...

journal_title：Cellular signalling

authors： Huang Q,Li J,Wang F,Oliver MT,Tipton T,Gao Y,Jiang SW

更新日期：2013-04-01 00:00:00

abstract：:Interferon-α (IFNα) has enormous potential for anti-proliferative and anti-viral treatments. However, clinical success is still hampered due to its limited bioavailability and thus, lack of sustained modulation of disease-relevant protective programs. Consequently, we here examined whether IFNα immobilized on nanoscal...

journal_title：Cellular signalling

authors： Pollok S,Ginter T,Günzel K,Pieper J,Henke A,Stauber RH,Reichardt W,Krämer OH

更新日期：2013-04-01 00:00:00

abstract：:p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function. The Cas family of ...

journal_title：Cellular signalling

authors： Barrett A,Pellet-Many C,Zachary IC,Evans IM,Frankel P

更新日期：2013-04-01 00:00:00

abstract：:Intracellular calcium signaling pathways play a major role in cellular responses such as proliferation, differentiation and apoptosis. Human embryonic stem cells (hESC) provide new possibilities to explore the development and differentiation of various cell types of the human body. Intracellular calcium responses to v...

journal_title：Cellular signalling

authors： Apáti Á,Pászty K,Hegedűs L,Kolacsek O,Orbán TI,Erdei Z,Szebényi K,Péntek A,Enyedi Á,Sarkadi B

更新日期：2013-04-01 00:00:00

abstract：:Forkhead-associated domain (FHA) is a phosphopeptide recognition domain embedded in some regulatory proteins. With similar fold type to important eukaryotic signaling molecules such as Smad2 and IRF3, the role of bacterial FHA domain is intensively pursued. Reported bacterial FHA domain roles include: regulation of gl...

journal_title：Cellular signalling

authors： Weiling H,Xiaowen Y,Chunmei L,Jianping X

更新日期：2013-03-01 00:00:00

abstract：:It has been shown lately that activity of G protein-coupled receptors (GPCRs) is regulated by an array of proteins binding to carboxy (C)-terminus of GPCRs. Proteins of 4.1 family are subsets of subcortical cytoskeletal proteins and are known to stabilize cellular structures and proteins at the plasma membrane. One of...

journal_title：Cellular signalling

authors： Goto T,Chiba A,Sukegawa J,Yanagisawa T,Saito M,Nakahata N

更新日期：2013-03-01 00:00:00

abstract：:Wnt5a, a non-transforming Wnt family member, plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in gastric cancer progression remains poorly defined. In this study, we found that Wnt5a dose-dependently stimulated the migration of human gastric cancer cells (SGC-7901), with the maxim...

journal_title：Cellular signalling

authors： Liu J,Zhang Y,Xu R,Du J,Hu Z,Yang L,Chen Y,Zhu Y,Gu L

更新日期：2013-02-01 00:00:00

abstract：:JNK signaling functions to induce defense mechanisms that protect organisms against a variety of different situations. The sestrin 2 gene, a p53-regulated member of the sestrins family, which lead to AMPK-dependent inhibition of TOR signaling, emerges as a novel player in autophagy induction. However, the relationship...

journal_title：Cellular signalling

authors： Zhang XY,Wu XQ,Deng R,Sun T,Feng GK,Zhu XF

更新日期：2013-01-01 00:00:00

abstract：:Our previous oligonucleotide array studies revealed that ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL) express high levels of the disheveled proteins (Dvls), a family of proteins that is integral to the Wnt signaling pathways. In this study, we assessed whether the Dvls are important in the pathogenesis of ...

journal_title：Cellular signalling

authors： Hegazy SA,Alshareef A,Gelebart P,Anand M,Armanious H,Ingham RJ,Lai R

更新日期：2013-01-01 00:00:00

abstract：:Hyperglycemia-induced endothelial dysfunction is characterized by enhanced inflammatory cytokine and adhesion molecule expression, and endothelial-monocyte adhesion. The adapter molecule CIKS (connection to IKK and SAPK/JNK; also known as Act1 or TRAF3IP2) is an upstream regulator of NF-κB and AP-1, and plays a role i...

journal_title：Cellular signalling

authors： Venkatesan B,Valente AJ,Das NA,Carpenter AJ,Yoshida T,Delafontaine JL,Siebenlist U,Chandrasekar B

更新日期：2013-01-01 00:00:00

abstract：:Proliferation of vascular smooth muscle cells (VSMCs) plays key roles in the progression of intimal hyperplasia, but the molecular mechanisms that trigger VSMC proliferation after vascular injury remain unclear. c-Ski, a co-repressor of transforming growth factor β (TGF-β)/Smad signaling, was detected to express in VS...

journal_title：Cellular signalling

authors： Li J,Li P,Zhang Y,Li GB,Zhou YG,Yang K,Dai SS

更新日期：2013-01-01 00:00:00

abstract：:Ubiquitination controls multiple cellular processes relevant to cancer pathogenesis. Using Gene Set Enrichment Analysis of an mRNA transcriptome dataset, we have identified genes encoding components of the ubiquitin system that are differentially expressed in colorectal cancers as compared to normal colonic mucosa. Am...

journal_title：Cellular signalling

authors： Eide PW,Cekaite L,Danielsen SA,Eilertsen IA,Kjenseth A,Fykerud TA,Ågesen TH,Bruun J,Rivedal E,Lothe RA,Leithe E

更新日期：2013-01-01 00:00:00

abstract：:Lithium salts are important drugs to treat bipolar disorder. Previous work showed that lithium by enforcing the interaction between the transcription factor CREB and its coactivator CRTC1 enhanced cAMP-stimulated CREB-dependent gene transcription. Both CREB and CRTC have been implicated in neuronal adaptation, which m...

journal_title：Cellular signalling

authors： Heinrich A,von der Heyde AS,Böer U,Phu do T,Tzvetkov M,Oetjen E

更新日期：2013-01-01 00:00:00